6-[4-methyl-6-(4-nitrophenyl)-2-oxo-5-phenylmethoxycarbonyl-1-6-dihydropyrimidin-3-yl]hexanoic-acid has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for 6-[4-methyl-6-(4-nitrophenyl)-2-oxo-5-phenylmethoxycarbonyl-1-6-dihydropyrimidin-3-yl]hexanoic-acid and Breast-Neoplasms
Article | Year |
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Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.
The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. Topics: Adenosine Triphosphatases; Breast Neoplasms; Cell Proliferation; Female; HSP70 Heat-Shock Proteins; Humans; Molecular Chaperones; Peptoids; Pyrimidinones | 2008 |