6-[4-methyl-6-(4-nitrophenyl)-2-oxo-5-phenylmethoxycarbonyl-1-6-dihydropyrimidin-3-yl]hexanoic-acid and Breast-Neoplasms

6-[4-methyl-6-(4-nitrophenyl)-2-oxo-5-phenylmethoxycarbonyl-1-6-dihydropyrimidin-3-yl]hexanoic-acid has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 6-[4-methyl-6-(4-nitrophenyl)-2-oxo-5-phenylmethoxycarbonyl-1-6-dihydropyrimidin-3-yl]hexanoic-acid and Breast-Neoplasms

ArticleYear
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.
    Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6

    The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70.

    Topics: Adenosine Triphosphatases; Breast Neoplasms; Cell Proliferation; Female; HSP70 Heat-Shock Proteins; Humans; Molecular Chaperones; Peptoids; Pyrimidinones

2008